Antioxidant and Resveratrol Science
What Researchers Are Discovering

Antioxidants
*Antioxidant Capacities of Foods. J. Agric. Food Chem., Vol. 52, No. 12, 2004 4027

*Wu X, Beecher GR, Holden JM, Haytowitz DB, Gebhardt SE, Prior RL, J Agric Food Chem. "Lipophilic and Hydrophilic Antioxidant Capacities of Common Foods in the United States." 2004 Jun 16;52(12):4026-37

Bianca Fuhrman, Nina Volkova, Raymond Coleman, and Michael Aviram. "Grape Powder Polyphenols Attenuate Atherosclerosis Development in Apoplipoprotein E Deficient Mice and Reduce Macrophage Atherogenicity." Lipid Research Laboratory and Department of Anatomy and Cell Biology, Technion Faculty of Medicine, Rappaport Family Institute in the Medical Sciences and Rambam Medical Center, Haifa, Israel.

Red Wine
Joseph Kanner, Edwin Frankel, Rina Granit, Bruce German, and John Kinsella. J. Agric. Food Chem. (1994), "Natural Antioxidants in Grapes and Wines." 42, 64-69.

Golberg, D.M. Clinical Chemistry, "Does Wine Work?" 41/1, 14-16 (1995)

Edwin Frankel, Andrew Waterhouse, and Pierre Teissedre. J. Agric. Food Chem., (1995) "Principal Phytochemicals in Selected California Wines and Their Antioxidant Activity in Inhibiting Oxidation of Human Low-Density Lipoproteins." 43, 890-894.

Joe Vinson and Barbara Hontz. J. Agric. Food Chem. "Phenol Antioxidant Index: Comparative Antioxidant Effectiveness of Red and White Wines." Department of Chemistry, University of Scranton, Scranton, PA 18150, 1995, 43, 401-403.

Zenebe Pechanova, Bratis1 Lek Listy (2002), "Effects of Red Wine Polyphenolic Compounds on the Cardiovascular System." Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, Bratislavia, Slovakia, 103 (4-5); 159-165.

Susanne U. Talcott, University of Florida. "Polyphenolics From Red Wine In Cancer Prevention: Influence on Apoptosis in Human Leukemia Cells and Antioxidant Effects in Human Subjects." 2004.

Resveratrol
The Harvard Mouse Study
Joesph A. Baur, Kevin J Pearson, et. al. "Resveratrol Improves Health and Survival of Mice on a High-Calorie Diet." Nature Vol 444/16 November 2006/doi:10.1038/nature05354

Usha Pendurthi, Todd Williams, Vijay Mohan Rao, "Resveratrol, a Polyphenolic Compound Found in Wine, Inhibits Tissue Factor Expression in Vascular Cells: A Possible Mechanism for the Cardiovascular Benefits Associated with Moderate Consumption of Wine." Arteriosclerosis Thrombosis, and Vascular Biology 1999:19; American Heart Association.

Erik Olson, Jennifer Naugle, Xiaojin Zhang, Joshua Bomser, and Gary Meszaros. American Journal Physiology Heart Circulatory Physiology. "Inhibition of cardiac fibroblast proliferation and myofibroblast differentiation by Resveratrol."  288: H131-H1138, 2005.

Lincoln W Morton, Rima Abu-Amsha Caccetta, Ian B Puddey, Kevin D Croft (2000) "Chemistry And Biological Effects Of Dietary Phenolic Compounds: Relevance To Cardiovascular Disease" Clinical and Experimental Pharmacology and Physiology 27 (3), 152–159. doi:10.1046/j.1440-1681.2000.03214.x

Gembu Imamura, Alberto Bertelli, Aldo Bertelli, Hajime Otani, Nilanjana Maulik, and Dipak Das. American Journal Physiology Heart Circulatory Physiology. "Pharmacological Preconditioning with Resveratrol: An Insight with iNOS Knockout Mice." 282: H1996-H2003, 2002; 10.1152/ajpheart.01013.2001.

Brent Trela and Andrew Waterhouse. J. Agric. Food Chem. "Resveratrol: Isomeric Molar Absorptivities and Stability." 1996, 44, 1253-1257

Jette Young, Lars O. Dragsted, Bahram Danehvar, Soren T. Lauridsen, Max Hansen, and Brittmarie Sandstrom, British Journal of Nutrition. "The effect of grape-skin extract on Oxidative stress." (2000), 84, 505-513

Jen-Kun Lin and Shu-Huei Tsai. Proc. Natl. Sci. Council ROC(B). "Chemoprevention of Cancer and Cardiovascular Disease by Resveratrol." Institue of Biochemistry, National Taiwan University.

Paul Szmitko and Subodh Verma. American Journal Physiology Heart Circulatory Physiology. "Antiatherogenic Potential of Red Wine: Clinician Update." 288: H2023-H2030, 2005

Quercetin
Mridula Chopra, Patricia Fitzsimons, John Strain, David Thurnham, and Alan Howard. Clinical Chemistry. "Nonalcoholic Red Wine Extract and Quercetin Inhibit LDL Oxidation without Affecting Plasma Antioxidant Vitamin and Carotenoid Concentrations." 46:8 1162-1170 (2000).

Masanori Yoshizumi, Koichiro Tsuchiya, Kazuyoshi Kirima, Moe Kyaw, Yuki Suzaki, and Toshiaki Tamaki.  Quercetin Inhibits Shc- and Phosphatidylinositol 3-Kinase-Mediated c-Jun N-Terminal Kinase Activation by Angiotensin II in Cultured Rat Aortic Smooth Muscle Cells. Department of Pharmacology, The University of Tokushima School of Medicine, Tokushima, Japan. The American Society for Pharmacology and Experimental Therapeutics, Vol. 60, Issue 4, 656-665, October 2001.

Joshua D. Lambert, Jungil Hong, Guang-yu Yang, Jie Liao, and Chung S. Yang Inhibition of Carcinogenesis by Polyphenols: Eveidence From Laboratory Investigations. American Journal of CLinical Nutrition 2005:81(suppl);284S-91S. Printed in USA. ©2005 American Society for Clinical Nutrition

Yumiko Nakamura, Susumu Ishimitsu, and Yasuhide Tonogai. Effects of Quercetin and Rutin on Serum and Hepatic Lipid Concentrations, Fecal Steroid Excretion and Serum Antioxidant Properties. Division of Food Chemistry, National Institute of Health Sciences, Osaka Branch, 1-1-43, Hoenzaka, Chuo-ku, Osaka 540-0006, Japan

Ellagic Acid
Joon-Hee Lee, Jodie V. Johnson, and Stephen T. Talcott J. Agric. Food Chem., 53 (15), 6003 -6010, 2005. 10.1021/jf050468r S0021-8561(05)00468-1 "Identification of Ellagic Acid Conjugates and Other Polyphenolics in Muscadine Grapes" by HPLC-ESI-MS

Marielle Kaplan, Tony Hayek, Ayelet Raz, Raymond Coleman, Leslie Dornfield, Jacob Vaya, and Michael Aviram. Pomegranate Juice Supplementation to Artherosclerotic Mice Reduces Macrphage Lipid Peroxidation, Cellular Cholesterol Accumulation and Development of Artherosclerosis." Lipid Research Laboratory and Department of Anatomy and Cell Biology, Technion Faculty of Medicine, Rappaport Family Institute in the Medical Sciences and Rambam Medical Center, Haifa, Israel.

Proanthocyanidins and Soy Lecithin
Teresa Satue-Gracia, Marina Heinonen, and Edwin Frankel J. Agric. Food Chem. "Anthocyanidins as Antioxidants on Human LDL and Lecithin-Liposime Systems." Department of Food Science and Technology, University of California, Davis, CA 95616. 1997, 45, 3362-3367